Clinical trial subgroups: challenges and opportunities in describing the benefits of therapy.

نویسنده

  • John Spertus
چکیده

Heart disease is the leading cause of death in women in the United States.1 To combat this phenomenon, professional guidelines for primary and secondary prevention as well as sex-specific guidelines for women have been developed and promulgated.2–4 Despite these efforts, there remains some controversy surrounding the benefits of statin therapy in women,5 although a 2004 meta-analysis clearly demonstrated benefits for secondary prevention on nonmortal cardiovascular events.6 In light of these data, current secondary prevention guidelines endorse statin therapy as a class IA recommendation for all patients recovering from an acute coronary syndrome, not just men.7

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عنوان ژورنال:
  • Circulation. Cardiovascular quality and outcomes

دوره 4 3  شماره 

صفحات  -

تاریخ انتشار 2011